Biology of cancer : cell proliferation.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (41.10 min.) : sound, black and white.

00:41:10

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr Austin Crathorn, Dr S. Revell, Dr J. Roberts and Dr. G Steel. Made by University of London Audio-Visual Centre for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Opening credits. Dr Austin Crathorn gives a general introduction of cell replication, narrating over films of cells growing and dividing, and discussing the cells' developments in detail. He also talks about the cells' DNA, displayed in diagrams, and about cell survival after doses of radiation. He shows a Petri dish of cell colonies made by cells that survived a dose of x-rays. He then introduces Dr Revell. Time start: 00:00:00:00 Time end: 00:07:31:19 Length: 00:07:31:19

Segment 2 Dr Revell talks about the effects of radiation on cells at the cellular and chromosomal level, showing photomicrographs of hamster cells; one received no radiation dose and the other has been damaged by radiation. Revell discusses the chromosome damage then goes on to talk about how radiation affects cell division. He also talks about the affect of x-rays on cell colony growth, using photomicrographs to illustrate his points. Time start: 00:07:31:19 Time end: 00:15:53:02 Length: 00:08:21:08

Segment 3 Dr Roberts begins his section of the lecture on how the damaged call overcomes damage to its DNA. He refers to diagrams and photographs throughout his talk. He discusses excision repair and post-replication repair. Time start: 00:15:53:02 Time end: 00:23:38:19 Length: 00:07:45:17

Segment 4 Dr Steel introduces his part of the lecture on cell population kinetics and tumour growth. He considers the proliferation of cells in vivo and its relationship to therapeutic response. First he summarises information about the kinetic state of cells in tumours and in normal tissues. Time start: 00:23:38:19 Time end: 00:28:50:18 Length: 00:05:11:24

Segment 5 Dr Steel continues his section and refers to various studies. He also talks about natural death amongst tumour cells and about tumour stem cells. Time start: 00:28:50:18 Time end: 00:35:57:10 Length: 00:07:06:17

Segment 6 Steel continues his section and talks about using assays for tumour stem cells to test the behaviour of cancer cells. He discusses two charts showing the affects of radiation on cells. He concludes the lecture. End credtis. Time start: 00:35:57:10 Time end: 00:41:10:06 Length: 00:05:12:21