A study of some fatal cases of malaria / by Lewellys F. Barker.

  • Barker, Lewellys F. (Lewellys Franklin), 1867-1943.
Date:
1895
Catalogue details

Licence: Public Domain Mark

Credit: A study of some fatal cases of malaria / by Lewellys F. Barker. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    fluid exudes from the cortical substance on pressure. The glomeruli are indistinct. The pancreas is oedematous. The adrenal glands are normal in size but it is noticeable that they are darker in color than normal. The stomach is moderately dilated; both it and the intestines con- tain an excess of mucus. The intestines are generally distended and their walls are oedematous. The bone-marrow is intensely pigmented, reddish-brown in color. The brain is small, especially in the frontal regions; weight, 940 grams. The pia is firmly adherent. No marked pigmentation. No hemorrhages or focal disease. The Blood.—Examined fresh from the peripheral veins and various internal organs showed enormous numbers of malarial parasites, most of them nearly full grown, others only half grown (tertian type), many of them enclosed within the protoplasm of large mononuclear leuco- cytes. No flagella seen. Frozen Seetions of the kidney show a very little fat in fine droplets in the glomeruli. The epithelial cells of the tubules in the labyrinth are much swollen and are filled with fine albuminous granules and hyaline droplets. Many of the tubules are dilated and are lined by low epithelium. Casts are numerous in sections and in urine collected from the bladder. Coagulated albumen is visible in the capsular spaces, in frozen sections made from bits of kidney previously fixed in boiling water. The capsular epithelium is swollen and evidently proliferated. Bacteriological Examination. (Dr. Flexner.) Cover slips from the heart's blood prepared and stained in the ordinary way showed numerous chains of streptococci. Cultures.—At the autopsy, the surface of the organs was burned with a hot knife, punctured through the burned area, and tubes of agar- agar were inoculated from the internal tissues. Esmarch roll-tubes were employed; after being kept in the thermostat for twenty-four hours at 37° C they were examined with the following results : The tube from the lung was found to be closely crowded with extremely minute colonies of streptococci, no other micro-organisms being present. The heart's blood, kidney, liver, bone-marrow and spleen all yielded many colonies of streptococci, here also in pure cultures. The tube from the spleen contained many more colonies than that from the liver.