A study of some fatal cases of malaria / by Lewellys F. Barker.

  • Barker, Lewellys F. (Lewellys Franklin), 1867-1943.
Date:
1895
Catalogue details

Licence: Public Domain Mark

Credit: A study of some fatal cases of malaria / by Lewellys F. Barker. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    nuclei as a rule stain sharply, and their protoplasm does not appear to be abnormal. At other times the protoplasm of the included cells is more highly refractive than normal, and has a clear glassy look; the nuclei may be fragmented and stain intensely, or they may be entirely necrotic and refuse to take up any of the ordinary nuclear dyes. When the large cell is necrosed (hyaline protoplasm, fragmented or non-staining nucleus) and contains within it white blood corpuscles, these are likely?to be leucocytes with polymorphous nuclei. Finally in the protoplasm of the makrophages (the case being one of general streptococcus infection) cocci occur singly, in chains, or in groups of chains; sometimes the streptococci lie within the protoplasm of included white blood corpuscles. The makrophages above described lie usually close to the walls of the capillaries but do not appear to have any organic connection with the walls. Sometimes a single one is large enough to practically close the lumen of a capillary. They appear, too, to be lodged quite fre- quently at the junction of capillaries and to cause obstruction to the flow of blood. There is an astonishingly large number of well preserved tertian malarial organisms, nearly fully developed, present in the liver. A comparatively small proportion of these apparently uninjured organ- isms are free in the blood or enclosed simply in red blood corpuscles. The majority of those in the blood-vessels are enclosed within the protoplasm of the large mononuclear leucocytes, from one to six in a cell, and a few within the protoplasm of leucocytes with polymorphous nuclei; although in these latter one rarely sees more than one or two in a cell. As has already been mentioned, a few well preserved ma- larial parasites are found among the contents of the free makrophages, and as will be pointed out later, occasionally uninjured parasites at the same stage of development as those in the blood are discernible inside the endothelial cells lining the hepatic capillaries. All these organisms appear to be of the same size and present very much the same appearances. They are nearly full grown and ready for seg- mentation ; indeed two definite segmenting bodies (central pigment surrounded by minute oval hyaline bodies) were seen in the blood in one section of the liver. The malarial organisms in alcohol sections in this case studied carefully with the best apparatus are seen to be tolerably regular spheres, consisting of a thin peripheral layer in which