Bilharziosis / by Frank Cole Madden.

  • Madden, Frank Cole.
Date:
1907
Catalogue details

Licence: Public Domain Mark

Credit: Bilharziosis / by Frank Cole Madden. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    and sometimes almost fill it. They are very vascular and, have the structure of loose fibrous tissue covered with a thickened mucous membrane, which is infil- trated with ova, and, at first, they are covered with epithelium. Later, on the surface of the elevations small pits and finally ulcers may form, the surface epithelium having necrosed, exposing a richly vascular and highly cellular granulation tissue. The whole viscus affected with this change is always very much thickened, and many of the earlier, more superficial, changes are present in what remains of the mucous membrane. Papillomata and sessile masses often occur side by side in the same organ. Ulceration.—Sometimes small pits may be found in the mucous membrane without any papillomatous or sessile changes. These may be scattered over the surface, perhaps in the midst of a sandy patch, or, sometimes as the principal lesion in a thickened, in- filtrated bladder. Then, again, ulcers may be the second stage of the vesicular formation already men- tioned, the vesicle bursting and a minute necrosis of the tissue taking place, owing to the obstructed blood supply caused by the presence of ova and small celled infiltration; in other cases crevices form at the base of papillomata or over a sandy patch and ulti- mately form ulcers. At a later stage of the disease larger and more definite ulcers may form, especially in the intestine. They are produced by the separ- ation of a papilloma from its base. A distinct ring of necrosing tissue is seen round the pedicle, and the