Genetic rearrangements in leukaemia and lymphoma / J.M. Goldman, D.G. Harnden.

Date:
1986
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic rearrangements in leukaemia and lymphoma / J.M. Goldman, D.G. Harnden. Source: Wellcome Collection.

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    168 GENETIC REARRANGEMENTS experiments have yet to be reproduced by others. Activated ras genes have also been detected in BL tumours but only rarely (two cases)^'*'^^. Until recently, only two main methods were available for identifying cellular oncogenes: either through isolation of their viral counterparts, or by isolation from malignant transformed NIH-3T3 after DNA mediated transfection. Information gained from molecular studies of BL chromosomal translocations may make it possible to envisage new strategies for oncogene identification. For instance, it has been suggested that by taking advantage of specific chromosomal translocations to the Ig locus in other B-cell neoplasia and to T- cell receptor genes in T-cell lymphomas and leukaemias the genes involved in the neoplastic process could be isolated if they moved to become adjacent to the Ig or T cell receptor locus. Some results already obtained in some B-cell neoplasia with either t(l 1; 14) or t( 14; 18) are very encouraging in this regard^^'^^. Acknowledgements Several experiments reported in this review were performed in the laboratory of Dr P Leder, Department of Genetics, Harvard Medical School, Boston MA 02115 with grant support from E J D Pont de Nemours and Company Ine and from the American Business Cancer Research Foundation. REFERENCES 1. Bishop J M 1983 Cellular oncogenes and retroviruses. Annual Review of Biochemistry 52: 301-354 2. Tabin C, Bradley S, Bargmann С, Weinberg R, Papageorge A, Scolnick E, Dhar R, Lowy D, Chang E 1982 Mechanisms of activation of a human oncogene. Nature 300; 762-765 3. Yunis J 1983 The chromosomal basis of human neoplasia. Science 221: 227-236 4. Nowell P C, Hungerford D A 1960 A minute chromosome in human granulocytic leukemia. Science 132: 1497 5. Rowley J D 1973 A new consistent chromosomal abnormality in chronic myelogenous leukaemia. Nature 243: 290-293 6. Manolov G, Manolova Y 1972 Marker band in one chromosome 14 from Burkitt lymphomas. Nature 237: 33-34 7. Zech L, Haglund U, Nilsson K, Klein G 1976 Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Burkitt lymphomas. International Journal of Cancer 17: 47-56 8. Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P 1982 Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt's lymphoma and murine plasmacytoma cells. Proceedings of the National Academy of Sciences USA, 79: 7837-7841 9. Burkitt D P 1958 A sarcoma involving the jaws in African children. British Journal of Surgery 46: 218-223 10. Burkitt D P 1962 A children's cancer dependent on climatic factors. Nature 194: 232-234 11. O'Conor G T 1961 Malignant lymphoma in African children. II. A pathological entity. Cancer 14: 270-283 12. Wright D H 1963 Cytology and histochemistry of the Burkitt's lymphoma. British Journal of Cancer 17: 50-55 13. Berard С W, O'Conor G T, Thomas L B, Torloni H (eds) 1969 Histopathological definition of Burkitt's tumour. Bulletin of the World Health Organization 40: 601-607