On the mydriasis produced by the local application of cocaine to the eye / by Walter H. Jessop.

  • Jessop, Walter H.
Date:
[1885]
Catalogue details

Licence: Public Domain Mark

Credit: On the mydriasis produced by the local application of cocaine to the eye / by Walter H. Jessop. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    an increase in the mydriasis occurs very quickly. The increase does not act to light or accommodation. A. G., 16. Under atropine (4 grains to the ounce three times a day for ten days), both pupils 9 mm. and equal, not acting to light or movements of accommodation. In left eye cocaine 4 per cent., and in fifteen minates pupil 10 mm. In one case, however, in which atropine had been used for two months continually, the pupil was very much dilated, 10*5 mm., and here cocaine had no effect, the pupil being at its ad maximum dilata- tion. F. G., 17. Has been using atropine for two months; pupils equal, regular, 10*5 mm., there being a very thin ring of iris visible; five applications of cocaine 4 per cent, in right eye, and no effect on the size of pupil. The results of these two experiments led me to make a mixture of the two drugs, and by it an ad maximum dilatation of the pupil can be soon produced, which will not soon disappear like cocaine my- driasis. The good effects of this in iritis were pointed out by me last January, and since have been fully sustained by increased experience. E. G., 6. Pupils 5 mm., equal, act well to light and accommoda- tion; at 2.24 P.M. a gelatine disk (of cocaine -j^-^ grain and atropine ToVo grain) put on left cornea ; at 2.29 p.m. no effect on pupil, slight drooping of lower lid. 2.34 P.M., pupil 9 mm. when shaded, 6 mm. in light, or on accom- modating. 2.40 P.M., pupil 10 mm., acting slightly to light and accommodation. 2.42 P.M., pupil 11 mm., does not act to light and accommodation. In this case, then, in eighteen minutes we had an ad maximum dila- tation of the pupil. To test the difference in time between this and the action of the same quantity of atropine alone, the next experiment was done. This shows that in eighteen minutes no effect was noted on the pupil, and that in thirty-six minutes the pupil was only 9 mm., and the greatest dilatation attained was 9*5 mm. E. G., 6. 2.46 P.M., right eye, pupil 5 mm., atropine disk -g oVo gi'ain. 2.58 P.M., no effect. 3.4 P.M., no effect. 3.17 P.M., pupil 8 mm., does not act to light or accommodation. 3.22 P.M., pupil 9 mm. 3.45 P.M., pupil 9*5 mm,, and did not increase. Experiment IV.—Cocaine and Tjserine. The action of eserine on cocaine mydriasis was to induce myosis very easily. The myosis resembled that due to eserine alone. On investigating more carefully I found that on taking 2 per cent.