Cellular mechanisms in delayed hypersensitivity. Part 1.

UK : University of London, 1973.

1 encoded moving image (27 min.) : sound, black and white

00:27:16

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Professor John Turk. Introduced by Dr. Ian Gilliland. Produced by David Sharp.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Dr Ian Gilliland introduces Prof. Turk, Professor of Pathology at the Institute of Basic Medical Sciences. Prof. Turk explains what a hypersensitivity reaction is and what the two types of reaction are. He says that the prototype of all delayed hypersenstivity reactions is the tuberculin reaction. A table shows comparisons of different hypersensitivity reactions and Turk explains the data. Another table compares appearances of different reactions. A third table compares sensitisation of different reactions. Turk then explains the causes of delayed hypersensitivity, which are also listed in a table. Time start: 00:00:00:00 Time end: 00:05:29:14 Length: 00:05:29:14

Segment 2 Next, Turk gives information on other types of delayed hypersensitivity reactions, including the homograft reaction. Turk then explains the phases of delayed hypsersensitivity with the aid of a chart with movable parts. He changes the parts as he explains the phases. The stages of reaction are listed in a table. Time start: 00:05:29:14 Time end: 00:09:01:03 Length: 00:03:31:14

Segment 3 Turk next talks about lymphocytes found in the bone marrow. He explains the two types, B and T lymphocytes and how they may produce delayed hypersensitivity reactions. Next, Turk looks at histological sections of lymphocyte cells to illustrate their departmentalisation. A series of slides of lymph nodes is shown, and Turk explains the differences between them. Time start: 00:09:01:03 Time end: 00:14:25:15 Length: 00:05:24:12

Segment 4 Turk discusses a lymph node's response to an injection of an antigen. He discusses another picture of an electron micrograph of a plasma cell. Next, he talks about what happens during a relatively pure cell-mediated immune reaction. A series of slides of lymph nodes is seen as Turk explains the series of events that occur in this reaction. Time start: 00:14:25:15 Time end: 00:20:14:00 Length: 00:05:48:10

Segment 5 Turk talks about how blast cells divide, and shows a picture of an electron microscope view of the cells. The blast cells divide into two types of cell, and Turk discusses both of these and how they may be involved in the sensitisation process. A graph shows cell concentrations in lymph nodes and he explains how they react to antigen injections. Time start: 00:20:14:00 Time end: 00:25:29:00 Length: 00:05:15:00

Segment 6 Turk once again uses the movable chart to explain the recognition of antigen by lymphocyte cells. End credits. Time start: 00:25:29:00 Time end: 00:27:16:15 Length: 00:01:47:15