The molecular basis of ageing.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (25.52 min.) : sound, black and white.

00:25:52

University of London

Restricted

In English

Presented by Dr Robin Holliday. Introduced by Dr Ian Gilliland. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Gilliland introduces Dr Holliday. Holliday discusses the history of research into the field of ageing. Time start: 00:00:00:00 Time end: 00:05:14:15 Length: 00:05:14:15

Segment 2 Holliday shows photomicrographs of cultured cells, focusing on the cell count against time. He shows further cells taken from individuals of varying ages. He then shows photographs of a man with Werner's syndrome (progeria). Time start: 00:05:14:15 Time end: 00:10:18:20 Length: 00:05:04:05

Segment 3 Holliday compares the ageing of normal cells with those in conditions such as Werner's syndrome. Time start: 00:10:18:20 Time end: 00:15:08:20 Length: 00:04:50:00

Segment 4 Holliday turns to more detailed molecular research into enzymes connected with the ageing process. He shows a graph of the results of ageing cells in culture from a patient with Werner's syndrome. Time start: 00:15:08:20 Time end: 00:20:32:00 Length: 00:05:23:05

Segment 5 Holliday describes an experiment which doubles the speed of ageing of cells. Time start: 00:20:32:00 Time end: 00:25:52:24 Length: 00:05:20:24