The constituents of the seeds of Hydnocarpus wightiana and of Hydnocarpus anthelmintica : isolation of a homologue of chaulmoogric acid / by Frederick Belding Power and Marmaduke Barrowcliff.

  • Power, Frederick B. (Frederick Belding), 1853-1927.
Date:
[1905]
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: The constituents of the seeds of Hydnocarpus wightiana and of Hydnocarpus anthelmintica : isolation of a homologue of chaulmoogric acid / by Frederick Belding Power and Marmaduke Barrowcliff. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    12/20 (page 893)
    II. The Constituents of the Seeds of Hydnocarpus anthelmintica {Pierre). A large quactity of these seeds was obtained for us in Siam, and their genuineness verified. When the kernels from 20 grams of the seeds were crushed and mixed with water, a distinct odour of hydrogen cyanide was soon developed, thus indicating that they contained a cyanogenetic gluco- side. An attempt was accordingly made to isolate this substance from 2 kilograms of the seeds, employing the same method as was successful in obtaining gynocardin from the seeds of Gynocardia odorata, R.Br. (Power and Lees, Trans., 1905, 87, 352). The amount of glucoside present was, however, very small, and nothing crystalline was obtained. The seeds were first divested of their shells, which represented 68‘8 per cent, of their weight. The kernels were then subjected to hydraulic pressure, and afforded an amount of a fatty oil and of a “press-cake” equivalent, respectively, to 16‘3 and 15 per cent, of the entire seeds. By completely extracting the total powdered seed with ether, 17'6 per cent, of oil was obtained. The Fatty Oil. The oil from the seeds of Hydnocarpus anthelmintica is, at the ordinary temperature, a nearly colourless, firm solid, having the same characteristic odour as is possessed by both chaulmoogra oil and that from the seeds of H. Wightiana. Its values were determined with the following results : Expressed oil. Oil extracted by ether. Melting point..., 24—25° 23—24° Specific gravity 0'953 at 25° 0’952 at 25° [a]i) in chloroform -l-52’5° 4-51° Acid value 7*5 8'1 Saponification value ... 212'0 208'0 Iodine value 86’4 82'5 Hydrolysis of the Fatty Oil. One hundred grams of the oil were hydrolysed with alcoholic potassium hydroxide, and the product extracted with light petroleum in the manner described on p. 886. The residue from the petroleum was exceedingly small in amount. After several crystallisations from alcohol, it was obtained in the form of glistening crystals melting at 132—133°, and was identical with the phytosterol obtained from the seeds of Hydnoca/rpus Wightiaoia.