Genetics of autoimmunity / [editors: Gregory Bock and Jamie Goode].

Chichester ; Hoboken, NJ : John Wiley, 2005.

viii, 251 pages : illustrations ; 24 cm.

"Symposium on Genomics of Autoimmunity, held at the Novartis Foundation, London, 22-24 June 2004"--Contents p.

Includes bibliographical references and indexes.

Patterns of genetic variation in humans and mice -- Haplotype tagging in pharmacogenetics -- Multiple sclerosis: a haplotype association study -- Mapping genes for asthma and psoriasis -- Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse -- The importance of epistatic interactions in the development of autoimmunity -- Mapping autoimmune disease genes in humans: lessons from IBD and SLE -- A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease -- Progress towards understanding the genetic pathogenesis of systematic lupus erythematosus -- A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling -- Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity -- An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells -- Large-scale screens for cDNAs with in vivo activity -- Genomic mining of new genes and pathways in innate and adaptive immunity.