Tyrosine protein-kinase Src,a proto-oncogene

Molecular model of side close-up of the proto- oncogene tyrosine- protein kinase Src (PDB code:1FMK), which is maintained in the inactive state by intramolecular interactions of SH2 and SH3 domains. The ribbon diagram shows the part of the linker connecting the SH2 and kinase domains sandwiched in PPII conformation between the SH3 and Kinase domains as a blue cylinder with residues in contact with SH3 domain as ball-and- stick models. The auto-inhibitory phosphotyrosine 527 bound to the SH2 domain is also shown.