Infectious multiple drug resistance / S. Falkow.

  • Falkow, Stanley.
Date:
1975
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Infectious multiple drug resistance / S. Falkow. Source: Wellcome Collection.

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    Pion advanced biochemistry series 4 INFECriOUSMULTIPLE DRUG RESISTANCE S.Falkow, Department of Microbiology, University of Washington, Seattle This volume is a documented guide to the study of infectious multiple-drug resistance (R) factors and otheribacterial plasmids. The first three chapters review the properties of the classicalT-factor and the bacteriophage X so that they may serve as the prototypes for the comparison of the broader spectrum of extrachromosomal elements that'are found in Nature. From this base of information there follows ah analysis in depth of the genetics, molecular nature, and replication of R-factors and other plasmids.' Particular emphasis is placed on the more recent research developments, including the classification of R-factors by their incompatibility properties, electron microscope heteroduplex analysis, the use of restriction endonucleases for the dissection of the plasmid genome, and the use of R-factors and other plasmids for 'cloning' genetic material. The ecology of R-factors and their implication'to human and veterinary medicine is covered in considerable detail vyith emphasis on the critical areas of nosocomial „ infection, the use of antibiotics'in animal feeds, the dissemination of R-factors m vivo, as well as the biochemical basis and origin of R-factor-mediated drug resistance. Although the R-factors are employed as the general model system, specific chapters also deal with the plasmids of the staphylococci and plasmids, guch as Ent and K88, which are known to contribute directly to bacterial pathogenicity. The book will be of prime interest to microbiologists, clinicians, research workers, and students in the fields of medicine, public health, veterinary medicine genetics, and molecular biology. It will also serve as a text for an introductory ■ course on Plasmids.' Other books in the series 1 Free radical mechanisms in tissue injury T.F.Slater 2 Biochemical reactors B.Atkinson 3 Brain function and macromolecular synthesis B.Jakoubek Series editor J. R. Lagnado Lecturer'in Biochemistry, Bedford College, University of London ISBN 0 85086 049 0 ' ' Pion Limited, 207 Brondesbury Park, London NW2 5JN, England Distributed by Academic Press, London and New Yorl< Now distnbuted by METHUEN&CO (worldwide excluding U.S.A.) and METHUEN INC. (U.S.A.)