The nature and origin of the poison of Lotus Arabicus / by Wyndham R. Dunstan and T.A. Henry.

  • Dunstan, Wyndham R. (Wyndham Rowland), 1861-1949.
Date:
1901
Catalogue details

Licence: In copyright

Credit: The nature and origin of the poison of Lotus Arabicus / by Wyndham R. Dunstan and T.A. Henry. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    in these cases being that each of these compounds contains a hydroxyl group in the so-called ortho position to a carbonyl group. This is the case with one hydroxyl group in the formulae given above for lotoflavin and luteolin. The decomposition products afforded by lotoflavin when fused with potash are identical with those given by morin, a colouring matter contained in Moras tinctoria. To the latter Bablich and Perkin (‘Journ. Chem. Soc.,’ vol. 69, 1896, p. 797) have assigned the following formula :— 0 OH OH CO The similarity of the decomposition products of morin and lotoflavin by fused potash are shown in the following scheme :— C15HJ0O7 + HoO + 30 = C6Hg03 + C7H604 + 2C0„. 0 OH COOH OH /VTY-« %0H 1 Iqh + H,0 + 30; OH /\ OH \/ /\ OH + ! I 2 \/ oh^o OH OH Morin. Phloroglucinol. /3-resorcylic acid. C15H10O6 + HoO + 20, = C0HA + C7H604 + 2COo. 0 OH COOH OH / \ OH X +H.0 + 20., OH OH OH II + + pB\i/ \/ \/ oh qo OH Phloroglucinol. OH /3-resorcylic acid. Lotoflavin. In each case the phloroglucinol carboxylic acid, under the conditions of the experi- ment, forms phloroglucinol and carbon dioxide, whilst the side chains of the resorcinol compounds simultaneously formed, are oxidised to carboxylic groups producing /3-resorcylic acid. Morin is therefore to be regarded as a hydroxy-lotoflavin. There remains for consideration one point in which lotoflavin differs from most of the members of the quercetin group of colouring matters, viz., in its inability to form addition compounds with mineral acids or to replace acetic acid in the acetates of the alkali metals with the formation of a metallic derivative. It has, however, been shown by A. G. Perkin that so far only those members of