Atherosclerosis : Lipoproteins; structure and function.

London : University of London Audio-Visual Centre, 1975.

1 encoded moving image (28 min.) : sound, black and white.

00:27:35

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Dr David J Galton, Department of Medicine, St Bartholomew s Hospital and Dr Alan Chait, Department of Metabolism and Endocrinology, The London Hospital. Made by University of London Audio-Visual Centre for the British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Opening credits. Footage of unhealthy activities (e.g. walking alongside heavy traffic, smoking and fatty foods) is seen, as well as images of related medical activities (e.g. taking blood pressure, measuring body fat etc.). Dr Galton introduces the topic, beginning with the role of lipoproteins in fuel metabolism and using diagrams as aids. He explains carbohydrates and lipids, how the body absorbs them and their advantages and disadvantages. He also talks about transfer of fatty acids and the sizes of lipoprotein particles, shown in a chart. Time start: 00:00:00:00 Time end: 00:05:10:17 Length: 00:05:10:17

Segment 2 Dr Galton hands over to Dr Chait, who discusses the structure and composition of lipoprotein particles. He displays 2 3-dimensional models of lipoprotein molecules with illustrated centres showing their composition. He then briefly explains apoproteins. Time start: 00:05:10:17 Time end: 00:09:47:00 Length: 00:04:36:08

Segment 3 Dr Chait then considers the individual lipoprotein classes, of which there are four. He first discusses chylomicrons, explaining where they are found and their composition. Diagrams of molecular structures are also seen. He then talks about pre-beta-lipoproteins, a-lipoproteins and beta-lipoproteins. He goes on to explain how lipoproteins are separated by electrophoresis and ultracentrifugation. Footage of these processes is seen as Dr Galton explains how they are done. Time start: 00:09:47:00 Time end: 00:15:11:06 Length: 00:05:24:06

Segment 4 Dr Galton continues to explain ultracentrifugation as footage of the process is seen. He then examines each lipoprotein particle in turn to see how they function as a fat transporting system within the body. A diagram of an organ framework is seen. He begins with detailing chylomicron particles. He passes back to Dr Chait, who addresses pre-beta-lipoprotein particles. Time start: 00:15:11:06 Time end: 00:20:15:08 Length: 00:05:04:02

Segment 5 Galton then discusses the removal of these lipoproteins from the plasma, using diagrams as aids. Dr Chait then addresses the final two lipoproteins, beta and alpha-lipoproteins, again using diagrams. Time start: 00:20:15:08 Time end: 00:24:59:03 Length: 00:04:43:20

Segment 6 Chait continues to explain beta and alpha-lipoproteins. Galton then summarises the lipoprotein system, seen in a diagram. Time start: 00:24:59:03 Time end: 00:27:35:12 Length: 00:02:36:09