Genetic control of immune responsiveness : relationship to disease susceptibility / edited by Hugh O. McDevitt and Maurice Landy.

Date:
1972
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic control of immune responsiveness : relationship to disease susceptibility / edited by Hugh O. McDevitt and Maurice Landy. Source: Wellcome Collection.

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    Glossary of Terms and Definitions for Session I Because of the complexity of a number of the antigens referred to in this session, and because several shorthand terms have crept into usage in the discussions, the editors considered it desirable to include a glossary defining these antigens and terms for the benefit of the reader. Several shorthand designations and terms are used liberally throughout the discussions and need some general definition. These are: 1. T cell. This is taken to be a thymus-derived, antigen-reactive, immuno¬ competent lymphocyte. 2. В cell. This designation is used for bone marrow-derived, immuno¬ competent lymphocytes bearing surface immunoglobulin, functioning as the precursors of antibody-producing lymphocytes and plasma cells. 3. V-gene. This is the designation used for the structural gene coding for the variable region of a particular immunoglobulin, or for immuno¬ globulins of a particular class. 4. C-gene. This is the designation used for the structural gene coding for the constant region of immunoglobulin heavy and light chains. The following antigens are referred to several times in this session and are given abbreviated designations therein. Rather than redefine each of them throughout the text, we have chosen to define them in this glossary. PLL A linear polymer composed entirely of poly-L-lysine. DNP-PLL Poly-L-lysine substituted with dinitrophenyl groups on the epsilon amino groups of lysine. GA A linear polymer of glutamic acid and alanine. GL A linear polymer of glutamic acid and lysine. DNP-GL A linear copolymer of glutamic acid and lysine substi¬ tuted with dinitrophenyl groups on the epsilon amino groups of lysine. GT A linear copolymer of glutamic acid and tyrosine. GATio A linear copolymer of glutamic acid, alanine and tyro¬ sine in which tyrosine makes up 10% of the amino acid residues. BSA Bovine serum albumin. DNP-BSA Bovine serum albumin substituted with dinitrophenyl groups, the number of dinitrophenyl groups per mole- 3