Growth hormone receptor, molecular model
- T.Blundell & N Campillo
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Description
Molecular model of growth hormone (GH) and its
receptor GHR), ribbon diagram. Representation of
the general architecture of the 1:2 complex (PDB
code:3hhr). 2 receptor molecules in cyan and blue,
GH represented as cylinders. GH elicitis a variety
of biological activities mainly mediated by the
GHR. GH binds to two receptors mols., thereby
inducing signal transduction through receptor
dimerization. GH, secreted from the anterior
pituitary lobe, has multiple effects on growth,
metabolism and the immune system.