Growth hormone receptor, molecular model

Molecular model of growth hormone (GH) and its receptor (GHR), ribbon diagram. Representation of the general architecture of the 2:2 complex (PDB code:1axi). The two receptor molecules in yellow, the growth hormones in violet. GH elicits a variety of biological activities mainly mediated by the GHR. GH, synthesized in and secreted from the anterior pituitary lobe has multiple effects on growth, metabolism and the immune system.