On the pathological anatomy of multiple lymphosarcoma and its status with relation to Hodgkin's Disease / by W.G. MacCallum.

  • MacCallum, W. G. (William George), 1874-1944.
Date:
[1907?]
Catalogue details

Licence: In copyright

Credit: On the pathological anatomy of multiple lymphosarcoma and its status with relation to Hodgkin's Disease / by W.G. MacCallum. Source: Wellcome Collection.

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    instance do we possess any information as to the etiology, so that they must be discussed merely from their morphological characters. Perhaps the simplest alteration is that known as lymphatism, or the status lymphaticus, in which, without changes in the blood, all the lymph glands, lymphoid nodules in the intestine, and indeed all the other lymphoid tissue in the body, become increased in bulk by an increase in the number of lymphoid cells and in the size of the germinal centres. In this condition there is no question of an in¬ vasion of the adjacent tissue, and the capsules of the lymph glands are intact, although stretched. Whether this differs in any essential way from the so-called aleukemic lymphoma mentioned by Paltauf it is difficult to say. Good descriptions of this condition have been given by Blumer, Friedjung, and others. When some portion, if not all, of the lymphoid tissue is stimulated to the great production of new lymphoid cells, there occurs an increase in the bulk of that tissue. This may apparently occur anywhere in the widespread system of lymphoid tissues, even in the bone-marrow. According to Sternberg, there may be enlargement of lymph glands, accumu¬ lation of lymphoid cells in unusual tissues, as in the liver, skin, etc., but with no alteration of the morphology of the blood, and this state he describes as pseudoleukemia, a condition that anatomically and histologically completely resembles lymphatic leukemia, but differs from it in the condition of the blood. However accurate the ter¬ minology may be from an etymological point of view, it seems un¬ fortunate that this name should be used in this way, since it has been so long and so generally used to express the condition com¬ monly known in this country as Hodgkin’s disease. According to Pappenheim, the changes which we know as lymph¬ atic leukemia arise only when the affection of the lymphoid tissue involves also the bone-marrow; then the cells are swept in great numbers into the blood, and the symptom leukemia is produced. There may, however, be changes of a similar sort, if not quite the same, in the bone-marrow without the production of any leukemia. Thus, in all the conditions so far described, there is for some reason an increase in the bulk of the lymphoid tissue, due to their rapid proliferation of the lymphoid cells wherever they normally