The intravenous administration of neo-salvarsan in syphilis / by J.A. Nixon.

  • Nixon, John Alexander, 1874-1951.
Date:
1913
Catalogue details

Licence: In copyright

Credit: The intravenous administration of neo-salvarsan in syphilis / by J.A. Nixon. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    C A Reprint from “ The Bristol Medico-Chirurgical Journal,” BY J. A. Nixon, M.B. Cantab., F.R.C.P. Physician and Physician-in-Charge of Skin Department, Bristol Royal Infirmary. Neo-Salvarsan is a new derivative of Salvarsan, obtained by Professor Ehrlich by the action of Formaldehyde-Sulphoxylate ■ upon Salvarsan (Dioxydiamidoarsenobenzol). The resultant comjiound contains as its active constituent Dioxydiamido- arsenobenzol-monomethane-sulphinate of sodium and bears the number 914 ” in Ehrlich’s series. The first great advantage of Neo-Salvarsan over Salvarsan is j the ease with which it dissolves in water. Unfortunately, like I many other organic arsenical compounds, it is unstable, and I readily oxidises, giving rise to products which are exceedingly ) toxic. ; My experience with this drug is short, but I am convinced t ^ that it possesses many advantages over the original Salvarsan I in the treatment of syphilis. The technique of administration is comparatively simple, but it demands close attention to detail. Neo - Salvarsan may be given intra - muscularly or intravenously ; but the latter is the method with which I propose to deal. McDonagh’s method of using a syringe for intravenous