The intravenous administration of neo-salvarsan in syphilis / by J.A. Nixon.

  • Nixon, John Alexander, 1874-1951.
Date:
1913
Catalogue details

Licence: In copyright

Credit: The intravenous administration of neo-salvarsan in syphilis / by J.A. Nixon. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    its various attachments may be safely laid down if necessary upon a sterilised surface. I find it convenient to stand the two beakers of Neo-Salvarsan and saline solution in a double pickle jar stand, so that both may be carried about and handed to me simultaneously. Solid particles or air-bubbles might prove fatal if injected into the vein. Should an air bubble by chance appear at the glass window tube, it must be at once drawn back again into the s5o:inge and allowed to float up to the top. The injection may then be continued. An air bubble of considerable size in the syringe does no harm if the syringe is held perpendicularly, and the plunger is not pushed home at each thrust so as to empty the sj^ringe. Personally, I prefer to keep a fairly large air bubble at the top of the syringe, as small bubbles if they occur in the solution can be more easily dislodged from the sides of the syringe and made to incorporate themselves in the larger bubble, which I watch constantly. The patients do not, as a rule, experience any unpleasant effects either during or after the injection. Some complain of a slight metallic taste at the end of the injection, but it is quite transitory. Occasionally a slight headache comes on two or three hours afterwards, and I find a cup of tea is the best remedy. It is advisable to prepare the patients as if for an anaesthetic by administering an aperient on the previous night, and giving a very light breakfast on the morning of the injection. Ordinary meals may be taken after the injection. The patients should remain at rest, preferably in bed, for two hours ; if at the end of that time no unpleasant S5'mptoms have occurred, I allow them to get up, provided they remain quiet. The first injection requires greater caution than subsequent ones so far as after treatment is concerned. If the patients stand the first injection well I allow them to get up and go out and about within a few hours after subsequent injections. The dosage I employ is 0.75 gramme (No. V) for a first injection in a healthy man, with subsequent injections of 0.9 gramme (No. VI), at intervals of three days (in practice