A comparison of the results obtained from the inoculation of portions of tissue affected with Paget's disease and of coccidia / by D'Arcy Power.

  • Power, D'Arcy, 1855-1941.
Date:
1893
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Licence: Public Domain Mark

Credit: A comparison of the results obtained from the inoculation of portions of tissue affected with Paget's disease and of coccidia / by D'Arcy Power. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    A COMPARISON OF THE RESULTS OBTAINED FROM THE INOCULATION OF PORTIONS OF TISSUE AFFECTED WITH PAGET'S DISEASE AND OF COCCIDIA. By D'Arcy Power, MA., F.E.C.S. (Eng.). From, the cmjoM Laboratories of the Eoyal Colleges of Physicians {Lmid.) and Surgeons {Eng.). I PROPOSE in this paper to compare the results obtained from the inoculation of pieces of tissue from cases of Paget's disease of the breast with those produced by the introduction of coccidia to the irritated mucous surfaces of animals. My method of procedure has been to paint the genital organs of white rats and rabbits daily with acetic acid, or with liniment of iodine, so as to keep the vagina or the glans penis in a state of slight irritation for long periods of time. Certain forms of protozoa are said to grow in epithelial tissues, and I thought that the warmth and moisture of the generative organs would be a convenient place for their artificial incubation, whilst the chronic irritation of the epithelial cells might be of service in promoting their development. It is unnecessary here to detail the interesting histological residts obtained from this method, as they have already been dealt with in a paper which I read before the Pathological Section of the British Medical Association.^ Suffice it to say, that I commenced my experiments by the introduction of pieces of freshly-removed scirrhus, encephaloid, and colloid cancers and epithelioma into the generative tracts of properly » prepared animals. In no case did I get the remarkable intermittent vaginal discharge, which will presently be described, as occurring after the introduction of pieces of epithelium from cases of Paget's disease of the breast, and of coccidia obtained from the rabbit's liver. The experiments were as follows :— r. The Inthoduction op Pieces of Paget's Disease of the Nipple. 1. I took a portion of breast, including the akin, from a case of Paget'.s disease of the iiipj)le, and being careful to avoid the immediate neigliboiu'hood of tlie ulcerated part, within lialf an liour of its removal from the body I pushed it into the vagina of a white rat which had been kept slightly irritiited ' Brit. Med. Joum. 1893, vol. ii. p. 830.